The double balloon enteroscopy (DBE) system (Fujinon Inc., Saitama, Japan) has been available for use in the United States since 2004 following initial development by Yamamoto el al.1 This system combines an enteroscope and overtube, both equipped with latex balloons which are insufflated/deflated in alternating cycles to pleat the bowel onto the overtube. DBE technique allows for intubation in the deep small bowel with therapeutic capability and access to the entire gastrointestinal tract lumen in many cases. Evolution of Device Assisted Enteroscopy (DAE)
Following the introduction of DBE, additional technologies were developed for intubation of the deep small bowel applying the same principle of small bowel pleating. Single balloon enteroscopy (SBE) (Olympus Optical Co, Tokyo, Japan) was introduced in 2007 followed by spiral enteroscopy (SE) in 2008 (Spirus Medical LLC,
West Bridgewater, MA, USA).2,3 More recently, the NaviAid device (SMART Medical Systems Ltd., Ra’anana Israel) was approved as a throughthe-scope balloon catheter which facilitates advancement of a standard colonoscope into the deep small bowel for “balloon-guided endoscopy (BGE)”.4 An enteroscope with a motorized, spiral tip is currently in development which may decrease procedure time and increase total enteroscopy rates.5 These techniques are all collectively known as device assisted enteroscopy (DAE) procedures. Double Balloon Enteroscopy Equipment DBE requires a base Fujinon endoscopy processor and light source combined with a balloon pump controller and DBE enteroscope (Figures 1a,1b,1c). The utilization of DBE in the U.S. has been somewhat limited by the prevalence of Olympus endoscopy equipment compared to that of Fujinon. In facilities in which an Olympus or other non-Fujinon system is already in use, it may be challenging to justify the capital expense of a second endoscopy system for this specialized procedure.
available in a standard, 200cm length with 3.2mm (therapeutic) accessory channel (EN-580T) as well as a shorter, 155cm length with a 3.2mm accessory channel for altered anatomy ERCP procedures (EI580BT). The 3.2mm channel, as well as the 2.8mm channel found in older models (EN-450T5), allows for passage of nearly all standard instruments.6 A slim-version 200cm enteroscope (EN-580XP) is also currently available for pediatric procedures. This model has a reduced diameter but a smaller accessory channel.
• Additional Equipment
A pressure-regulated air pump controls the exchange of air to and from the balloons for insufflation/deflation. This pump system includes tubes and diaphragms which are multiuse. Carbon dioxide insufflation of the small bowel lumen has been found to increase insertion depth while decreasing symptoms of abdominal distension postprocedure compared to examinations using air.7,8 Therefore, a CO2 controller should be employed. Complementary equipment for DBE includes a Fujinon ST-10 balloon setting tool (Figure 2a), Zutron stiffening device (Figure 2b) and instrument cap with irrigation port (Figure 2c).
The choice of sedation is dependent on the length of the procedure, patient characteristics and individual preference. Endotracheal intubation is often appropriate for long anterograde DBE procedures while moderate sedation is safe for retrograde exams and shorter anterograde exams. Fluoroscopy is no longer commonly used as a complement to DBE but may be beneficial in select cases.
Standard Performance of DBE
Double balloon enteroscopy may be performed via anterograde or retrograde route. Total enteroscopy rates (TER) for DBE range from 16-86% with a pooled rate of 44% reported in a recent, large meta-analysis.9,10 Although total enteroscopy is achievable through anterograde DBE alone, it is most commonly accomplished using a combination of anterograde and retrograde approaches with a submucosal ink tattoo placed at the maximal insertion site of the initial approach. Total enteroscopy rates with DBE are impacted by Figures 1a, 1b, & 1c. Fujinon endoscopy processor & light source (1a), balloon pump controller (1b) and enteroscope (1c) *with permission from Fujinon*
small bowel pathology as well as access to the diverted stomach and ampulla in patients with surgically altered anatomy. It has also been shown to be effective in completing difficult colonoscopy examinations such that the adoption of DBE for this indication has expanded over time. A list of DBE indications is included in Table 2.
There are several conditions in which DBE has little or no demonstrated utility but is often contemplated. DBE is not routinely indicated in the evaluation of patients with disorders of gutbrain interaction (DGBIs), formerly functional gastrointestinal disorders (FGIDs).17 Small bowel obstruction due to adhesions or intestinal carcinomatosis is not managed with DBE, although one series of 4 cases has been published describing
the benefit of push enteroscopy in treating early post-operative bowel obstruction.18 DBE is not indicated to exclude a diagnosis of small bowel Crohn’s disease after negative video capsule endoscopy (VCE) as VCE has a high negative
predictive value for this indication.19
- Small Bowel Bleeding
DBE has a diagnostic yield of up to 60-80% in cases of suspected small bowel bleeding. VCE produces a similar diagnostic yield for this indication but is less invasive.9 Therefore, DBE is generally recommended after abnormal VCE as a therapeutic procedure to treat identified bleeding sources. DBE is indicated after normal VCE in patients under the age of 50 as small bowel tumors may be missed by VCE in 18% of cases.20,21 (Figures 3a & 3b)
DBE is also indicated after normal VCE in patients older than age 50 who experience continued blood loss as evidence by a drop in hemoglobin by > 4gm/dl or overt bleeding.9,22 Finally, DBE may be required to evaluate the pancreatobiliary intestinal limb and diverted stomach for bleeding sources in patients with altered anatomy such as long Rouxen-y gastric bypass.23 (Figures 4a & 4b)
- Abnormal Small Bowel Imaging
In patients with small bowel ulceration observed on VCE, DBE is often required to obtain tissue samples to confirm a diagnosis of Crohn’s disease, NSAID enteropathy or small bowel lymphoma. (Figures 5a, 5b, 5c) DBE may be performed as an alternative to VCE in patients with suspected small bowel Crohn’s disease who are at high risk for capsule retention. Abnormal small bowel imaging of the small bowel is also an indication for DBE when suggestive of a new diagnosis of small bowel tumor or other pathology. (Figures 6a & 6b)
- Altered Anatomy ERCP
Altered anatomy ERCP is an indication for DBE which requires a specialized skillset and equipment. The reported success rates of DBE-assisted ERCP in surgically altered anatomy varies by type of post-surgical anatomy. Success rates of up to 100% have been reported with DBE-ERCP in cases of Billroth II, Whipple pancreaticoduodenectomy and short-limb Roux-en-y anatomy. In patients with long-limb Roux-en-y anatomy, success rates for cannulation are much lower at 60-84%. (Figure 7) When considering DBE-ERCP, it is important to appreciate that the risk of post-ERCP pancreatitis is higher in altered anatomy ERCP due to challenging cannulation which often requires pre-cut sphincterotomy.24,25,26
The utility of DBE and other DAE methods in facilitating biliary access in long-limb Rouxen-y gastric bypass (RYGP) anatomy, has recently been studied head-to-head with alternative methods such as laparoscopic-assisted ERCP (LA-ERCP) and EUS-assisted transgastric ERCP (EDGE). In a recent cohort study comparing DAE-ERCP, LAERCP and EDGE in 130 patients, DAE-ERCP was successful in only 59% of patients in comparison with success rates of 98% for LA-ERCP and 100% for EDGE. EDGE was also associated with shorter
hospitalization and fewer adverse events.27 Many therapeutic endoscopists have adopted EDGE as their method of choice for biliary access in patients with long-limb RYGP as a result of this and similar studies.28
• Foreign Body Removal
Foreign bodies may be removed from the deep small bowel using DBE, including retained video capsules, motility capsules, self-expandable metal stents, intragastric bariatric balloon, dentures and other objects.29 A pooled success rate of 86.5% was reported in one large review of video capsule retrieval by DBE. Anterograde approach and jejunal location were predictors of success compared to retrograde approach and ileal location. The performance of DBE for video capsule retrieval also reduced the need for surgery for benign strictures and helped define strictures due to malignancy.30 Video capsule retention may be considered as a positive event in cases in which retention aids in localization of pathology. (Figure 8) Finally, DBE has a limited role in dilation of strictures of the small bowel related to Crohn’s disease, NSAID enteropathy or other benign etiologies.31 (Figures 9a, 9b & 9c) Intestinal Polyposis
Surveillance of intestinal polyposis syndromes including Peutz-Jeghers Syndrome (PJS) and Familial Polyposis (FAP) is an infrequent indication for DBE due to the rarity of these conditions. In patients with PJS, prophylactic resection of hamartomatous small bowel polyps >10mm in size may decrease the risk of repeated laparotomy require to treat intussusception, obstruction or bleeding.32,33,34 (Figures 10a & 10b) Each laparotomy increases the risk of future surgeries as well as risk of complications such as short bowel and intestinal obstruction due to adhesions.35 DBE may be useful in the surveillance of adenomatous polyps of the proximal small bowel in FAP.36 Balloon-Assisted Colonoscopy Double-balloon enteroscopy equipment has proven to be valuable in the completion of colonoscopy after failure of colonoscopy with standard equipment. A 2017 meta-analysis of 18 studies, including a total of 667 patients, described a successful completion
rate of >97% with DBE.37 A more recent study of 122 cases produced similar results with a 92% completion rate.38
Comparison of DAE Techniques
DBE, SBE, SE and BGE may all be considered for the above indications with advantages, disadvantages and limitations with each technique. Comparison trials have been performed for several of these indications which are useful for reference. However, the primary deciding factors in selection of DAE technique are: availability of the required equipment in the endoscopy unit and experience of the endoscopist. A summary of important comparisons are listed in Table 3.
- Total Enteroscopy Rate (TER) Total enteroscopy with DBE using a combination of anterograde and retrograde exams was reported as achievable in 86% of patient in the initial study.1 Although TERs have been lower in subsequent studies, DBE has been demonstrated to outperform SBE, SE and BGE in this regard. The average TER with DBE is 34% compared to 12% with SBE and 3% with SE, considering data from across multiple studies.39,40,41,42,43
- Procedure Time
Average procedure time with anterograde DBE is significantly longer at 76 +/- 6min compared to 60 +/- 10min for anterograde SBE and 41 +/- 4min for anterograde SE. Procedure times for retrograde DBE are also longer than SBE and SE.44
- Diagnostic Yield
The diagnostic yield of device-assisted enteroscopy is similar across all techniques at ~40 – 60% despite differences in TER.45,46,47 Lack of correlation between diagnostic yield and TER may be related to inclusion of upper GI tract abnormalities when calculating diagnostic yield for anterograde enteroscopy. The overall diagnostic yield of push enteroscopy ranges from 20-80% but half of abnormalities are found within reach of a standard gastroscope. Distribution of pathology within the small bowel may also explain similar diagnostic yield across techniques.48 Angioectasias, the most common pathology found on DAE, are most frequently observed in the proximal 1/3
of the small bowel which is within reach of all anterograde enteroscopy techniques.49 (Figure 11a & 11b). The diagnostic yield of anterograde DAE is comparatively higher than that of retrograde DAE likely for these same reasons.50
- Altered Anatomy ERCP
Successful completion of DAE-ERCP appears to be equal between DBE, SBE and SE techniques when studied in all types of surgically altered anatomy.28 There is a practical advantage to using a short (155cm) model enteroscope, now available for DBE and SBE, as it allows for the use of all accessories of standard length. For the challenging indication of DAE-ERCP in long limb surgical bypass, DBE, SBE and SE were compared within a cohort of 129 patients. Cannulation by DAE-ERCP was successful in 63% of cases overall with similar success rates between all three methods.51 These results are consistent with previous studies of DBE, SBE and SE in the performance of DAE-ERCP.
- Device-Assisted Colonoscopy
The success rate of colonoscopy with DAE equipment approaches 100% in individual as well as comparison studies regardless of DAE technique. The largest comparison study of double balloon and single balloon technique for colonoscopy in patients with previous incomplete exams using standard equipment demonstrated success rates of 93% & 100%, respectively with each method.52
Spiral enteroscopy and through-the-scope balloon catheters have also been utilized with success in completion of difficult colonoscopy cases.
The advent of double balloon enteroscopy in Japan (2001) then in the U.S. (2004) was an important milestone in gastrointestinal endoscopy as this technology allows for access to the entire small bowel for therapeutic intervention. This procedure is well tolerated and low risk, especially when compared to intraoperative enteroscopy. DBE equipment is currently utilized for a variety of endoscopic indications in addition to the common indication of small bowel bleeding. Although additional technologies for DAE have been subsequently developed, DBE has an advantage over other DAE techniques in regard to rate of total enteroscopy. The performance of DBE in the U.S. may be inhibited by availability of Fujinon endoscopy systems. However, the DBE system should be considered as an essential tool for centers which manage a significant volume of patients with small bowel bleeding or other small bowel pathology.
- Yamamoto H, Sekine Y, Sato Y et al. Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc 2001;53:216–220.
- Hartmann D, Eickhoff A, Tamm R, Riemann JF. Balloon-assisted enteroscopy using a single-balloon technique. Endoscopy 2007;39 Suppl 1:E276.
- Akerman PA, Agrawal D, Cantero D, Pangtay J. Spiral enteroscopy with the new DSB overtube: A novel technique for deep peroral small-bowel intubation. Endoscopy 2008;40:974–978.
- Ali R, Wild D, Shieh F, et al. Deep enteroscopy with a conventional colonoscope: initial multicenter study by using a through-the-scope balloon catheter system. Gastrointest Endosc 2015 Nov; 82(5):855-860.
- Beyna T, Arvanitakis M, Schneider M et al. Total motorized spiral enteroscopy: first prospective clinical feasibility trial. Gastrointest Endosc 2021 Jun;93(6):1362-1370.
- Lo SK, Medhizadeh S. Therapeutic uses of double-balloon enteroscopy. Gastrointest Endosco Clin N Am 2006;16:363-376.
- Domagk D, Bretthauer M, Lenz P et al. Carbon dioxide insufflation improves intubation depth in double-balloon enteroscopy: a randomized, controlled, double-blind trial. Endoscopy 2007:39:1064-1067.
- Dellon ES, Hawk JS, Grimm IS et al. The use of carbon dioxide for insufflation during GI endoscopy: a systematic review. Gastrointest Endosc 2009;69:843-849.
- Gerson LB, Fidler JL, Cave DR, Leighton JA. ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding. Am J Gastroenterol 2015;110(9):1265-1287.
- Xin L, Liao Z, Jiang Y, Li ZS. Indications, detectability, positive findings, total enteroscopy, and complications of diagnostic double-balloon endoscopy: a systematic review of data over the first decade of use. Gastrointest Endosc 2011;74(3):563-570.
- Gross S, Stark M. Initial experience with double-baloon enteroscopy at a US center. Gastrointest Endosc 2008;67(6):890-897.
- Raines DL, Arbour A, et al. Variation in small bowel length: a factor in achieving total enteroscopy? Digestive Endoscopy 2015;27(1):67-72.
- Acosta R, Abraham NS, Chandrasekhara V et al. The management of antithrombotic agents for patients undergoing GI endoscopy. Gastrointest Endosc 2016;83(1):3-16.
- Raines DL, Spera M, Bollinger E. The safety and efficacy of deviceassisted enteroscopy in the setting of thienopyridine antiplatelet therapy. J Clin Gastroenterol 2017;51(1):e1-e4.
- Heine GD, Madithi M, Groenen MJ et al. Double-balloon enteroscopy: indications, diagnostic yield, and complications in a series of 275 patients with suspected small-bowel disease. Endoscopy 2006; 38(1):42-48.
- Gralnek IM. Complications of diagnostic colonoscopy, upper endoscopy, and enteroscopy. Best Pract Res Clin Gastroenterol 2016; 30: 705–718.
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- Huprich JE, Fletcher JG, Alexander JA et al. Obscure gastrointestinal bleeding: evaluation with 64-section multiphase CT enterography-initial experience. Radiology 2008; 246: 562-571.
- Raines DL, Hutchings JJ. Evaluation of obscure gastrointestinal bleeding after a negative capsule endoscopy. In Capsule Endoscopy by Case Study. Ed. Daniel Raines. Ambris Publishing. 2012
- Gurudu SR, Bruining DH, Acosta RD. The role of endoscopy in management of suspected small bowel bleeding. Gastrointestinal Endoscopy 2017;85(1):22-32.
- Skinner M, Peter S, Wilcox CM, Mönkemüller K. Diagnostic and therapeutic utility of double-balloon enteroscopy for obscure GI bleeding in patients with surgically altered upper GI anatomy. Gastrointest Endosc 2014; 80:181-186.
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- Schreiner MA, Chang L, Gluck M, et al. Laparoscopy-assisted versus balloon enteroscopy-assisted ERCP in bariatric post-Roux-en-Y gastric bypass patients. Gastrointest Endosc 2012;75:748-756.
- Siddiqui AA, Chaaya A, Shelton C, et al. Utility of the short double balloon enteroscope to perform pancreaticobiliary interventions in patients with surgically altered anatomy in a US multicenter study. Dig Dis Sci 2013; 58: 858-64
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