BMI, Diabetes, and Cholangiocarcinoma Risk

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Obesity and diabetes are associated with an increased liver cancer risk. To evaluate their relationship with intrahepatic cholangiocarcinoma (ICC), the second most common cause of liver cancer, a pooled analysis was conducted with a systemic review/meta-analysis of the literature. The liver cancer pooling project was a consortium of 13 U.S. based, prospective cohort studies with data from 1,541,143 individuals (ICC cases, N = 414). In this systematic review, 14 additional studies were identified and a meta-analysis was carried out, combining the results from LCCP with the results from the 5 prospective studies identified through September 2017.