Liver Disorders, Series #4

Primary Biliary Cholangitis

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Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic, cholestatic, inflammatory liver disease characterized by destruction of intrahepatic bile ducts resulting in progressive liver damage. The etiology of PBC is still not fully understood but likely involves both environmental and genetic factors. Here we provide a review of the etiology, pathogenesis, natural history, diagnosis and management of primary biliary cholangitis.

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