Recent Articles

Dispatches from the GUILD Conference, Series #75

Pharmacological Management of Chronic Constipation

Chronic constipation is a common and often burdensome condition encountered in both primary care and gastroenterology practice. Managing it effectively requires an understanding of constipation subtypes, exclusion of secondary causes, […]

Nutrition Reviews in Gastroenterology, SERIES #33

The Role of the Crohn’s Disease Exclusion Diet in Treatment and Management of Crohn’s Disease

The increasing incidence of inflammatory bowel disease underscores the importance of environmental factors, particularly nutrition, in disease development. Diet plays a key role in shaping the gut microbiome, modulating immune […]

efficacy and safety of peroral endoscopic myotomy for the treatment of achalasia: a systematic review. J Cardiothorac Surg. 2019;14(1):1. Published 2019 Jan 3. doi:10.1186/ s13019-018-0811-9 52 Rodríguez de Santiago E, Mohammed N, Manolakis A, Shimamura Y, Onimaru M, Inoue H. Anterior versus posterior myotomy during poem for the treatment of achalasia: systematic review and meta-analysis of randomized clinical trials. J Gastrointestin Liver Dis. 2019;28(1):107-115. doi:10.15403/jgld.2014.1121.281.pom 53 Vespa E, Barchi A, Mandarino FV, et al. Standard length of peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis. Dis Esophagus. 2024;37(12):doae069. doi:10.1093/dote/doae069 54 Zhang H, Zeng X, Huang S, et al. Mid-Term and Long- Term Outcomes of Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Systematic Review and Meta- Analysis. Dig Dis Sci. 2023;68(4):1386-1396. doi:10.1007/ s10620-022-07720-4 55 Zhong C, Tan S, Ren Y, et al. Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis. Ann Thorac Cardiovasc Surg. 2020;26(3):113-124. doi:10.5761/atcs. ra.19-00273 56 Shou Y, Wang X, Liu D. Factors associated with peroral endoscopic myotomy for achalasia outcomes: systematic review and meta-analysis. Surg Endosc. 2024;38(7):3503- 3519. doi:10.1007/s00464-024-10862-3 57 Andolfi C, Fisichella PM. Meta-analysis of clinical outcome after treatment for achalasia based on manometric subtypes. Br J Surg. 2019;106(4):332-341. doi:10.1002/ bjs.11049 58 Hayat U, Kamal F, Memon A, et al. Peroral Endoscopic Myotomy for Achalasia Among the Elderly Population: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. Published online February 10, 2025. doi:10.1097/ MCG.0000000000002103 59 Hayat U, Kamal F, Rana UI, et al. Efficacy and Safety of Repeat Per-oral Endoscopic Myotomy After Failed POEM for Achalasia: A Systematic Review and meta-analysis. J Clin Gastroenterol. Published online December 5, 2024. doi:10.1097/MCG.0000000000002117 60 Mota RCL, de Moura EGH, de Moura DTH, et al. Risk factors for gastroesophageal reflux after POEM for achalasia: a systematic review and meta-analysis. Surg Endosc. 2021;35(1):383-397. doi:10.1007/s00464-020-07412-y 61 Dhoop S, Abu-Rumaileh M, Sayeh W, et al. Efficacy and safety of full-thickness versus circular peroral endoscopic myotomy for treatment of achalasia: a systematic review and meta-analysis. Ann Gastroenterol. 2025;38(2):143-155. doi:10.20524/aog.2025.0946 62 Mohan BP, Ofosu A, Chandan S, et al. Anterior versus posterior approach in peroral endoscopic myotomy (POEM): a systematic review and meta-analysis. Endoscopy. 2020;52(4):251-258. doi:10.1055/a-1090-0788 63 Zhang H, Zeng X, Huang S, et al. Safety and Efficacy of Peroral Endoscopic Shorter Myotomy versus Longer Myotomy for Patients with Achalasia: A Systematic Review and Metaanalysis. Gastroenterol Res Pract. 2022;2022:6770864. Published 2022 Mar 30. doi:10.1155/2022/6770864 64 Weng CY, He CH, Zhuang MY, Xu JL, Lyu B. Peroral endoscopic longer vs shorter esophageal myotomy for achalasia treatment: A systematic review and meta-analysis. World J Gastrointest Surg. 2022;14(3):247-259. doi:10.4240/wjgs. v14.i3.247 65 Ghazaleh S, Beran A, Khader Y, et al. Short versus standard peroral endoscopic myotomy for esophageal achalasia: a systematic review and meta-analysis. Ann Gastroenterol. 2021;34(5):634-642. doi:10.20524/aog.2021.0644 66 Tan S, Zhong C, Ren Y, et al. Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta- Analysis. Gut Liver. 2021;15(2):153-167. doi:10.5009/ gnl19234 67 Zhong C, Ni B, Liu S, et al. The Effect of Peroral Endoscopic Myotomy in Achalasia Patients with Prior Endoscopic Intervention: A Systematic Review and Meta-Analysis. Dig Surg. 2021;38(2):136-148. doi:10.1159/000512627 68 Vespa E, Pellegatta G, Chandrasekar VT, et al. Longterm outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis. Endoscopy. 2023;55(2):167-175. doi:10.1055/a-1894-0147 69 Patel K, Abbassi-Ghadi N, Markar S, Kumar S, Jethwa P, Zaninotto G. Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis. Dis Esophagus. 2016;29(7):807-819. doi:10.1111/ dote.12387 70 Mota RCL, de Moura EGH, de Moura DTH, et al. Risk factors for gastroesophageal reflux after POEM for achalasia: a systematic review and meta-analysis. Surg Endosc. 2021;35(1):383-397. doi:10.1007/s00464-020-07412-y 71 Gopakumar H, Annor E, Vohra I, et al. Peroral endoscopic myotomy with fundoplication (POEM-F) for achalasia: Systematic review and meta-analysis [published correction appears in Endosc Int Open. 2025 Mar 19;13:a25624787. doi: 10.1055/a-2562-4787.]. Endosc Int Open. 2025;13:a25368132. Published 2025 Mar 14. doi:10.1055/a-2536-8132

Frontiers in Endoscopy, Series #107

Endoscopic Management of Achalasia

Introduction Achalasia is a rare, chronic motility disorder of the esophagus with a worldwide prevalence of 1.8 to 12.6 per 100,000 people. In the US, a study published in 2022 […]

Dispatches from the GUILD Conference, Series #74

Fertility and Use of Assisted Reproductive Technology among Women with Inflammatory Bowel Disease: A Practical Guide

Women with Inflammatory Bowel Disease (IBD) increasingly utilize assisted reproductive technologies (ART), such as in vitro fertilization (IVF) and oocyte cryopreservation. Women with active IBD or a history of pelvic […]

Nutrition Reviews in Gastroenterology, SERIES #32

The Gastrointestinal Side Effectsof GLP-1 Therapies: Understanding the Physiology to Prevent Malnutrition

Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have rapidly transformed the management of type 2 diabetes and obesity. While their cardiovascular and metabolic benefits are well established, their effects on the […]

Frontiers in Endoscopy, Series #106

Functional Lumen Imaging Probe (EndoFLIP)and EsoFLIP: Practical Indications, Interpretation, and Limitations

Introduction Advances in gastrointestinal functional testing have highlighted the limitations of relying on high-resolution manometry (HRM) alone to characterize esophageal pathology, especially with regards to manometric disturbances in patients with […]

Dispatches from the GUILD Conference, Series #74

Fertility and Use of Assisted Reproductive Technology among Women with Inflammatory Bowel Disease: A Practical Guide

Women with Inflammatory Bowel Disease (IBD) increasingly utilize assisted reproductive technologies (ART), such as in vitro fertilization (IVF) and oocyte cryopreservation. Women with active IBD or a history of pelvic […]

Nutrition Reviews in Gastroenterology, SERIES #31

Disorders of Gut-Brain Interaction: Behavioral Therapies and Integration of the GI-Psychologist and GI-Registered Dietitian Care

Effective management of Disorders of Gut-Brain Interaction (DGBIs) often requires an interdisciplinary approach that extends beyond the gastrointestinal (GI) provider. DGBIs are characterized by dysregulation of the gut–brain axis, and […]

Frontiers in Endoscopy, Series #105

Endoscopic Duodenal Mucosal Resurfacing

With prevalence of type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) rising in parallel, there is an increased need for alternatives to surgical and pharmacological treatments for these […]

from the pediatric literature

Capsule Endoscopy Yield in Pediatric Patients

Video capsule endoscopy (VCE) uses a small, wireless, capsule camera that is swallowed or placed endoscopically to evaluate the entirety of the gastrointestinal (GI) tract often beyond the reach of […]

Dispatches from the GUILD Conference, Series #73

Prevention and Management of Postoperative Crohn’s Disease

Postoperative recurrent Crohn’s disease is common and often clinically silent at onset, requiring objective assessments for diagnosis and surveillance. Patients with a history of multiple bowel resections, penetrating disease, or […]

Nutrition Reviews in Gastroenterology, SERIES #30

Racial and Ethnic Disparities in Dietary Patterns and Micronutrient Supplementation

Dietary disparities among racial and ethnic minority populations contribute significantly to chronic disease burdens across the lifespan. This review synthesizes evidence on dietary behaviors among middle-aged and older adults, adolescents, […]

Frontiers in Endoscopy, Series #104

Boerhaave Syndrome: An Updated Review with an Emphasison Endoscopic Treatments

Introduction  Spontaneous rupture of the esophagus is also known as Boerhaave syndrome after the Dutch physician who first described it in 1724.1 Historically, Boerhaave syndrome was considered uniformly fatal. Boerhaave […]

Dispatches from the GUILD Conference, Series #72

Computer-Aided Detection in Colonoscopy: Promise, Performance, and Real-World Questions

Computer aided polyp detection (CADe) is one of the most heavily studied applications of artificial intelligence in clinical medicine and may serve as a valuable adjunct for gastrointestinal endoscopists. Randomized […]

INTRODUCTION: DISPATCHES FROM THE GUILD CONFERENCE

Introduction: Dispatches from the 10th Annual GUILD Conference 2026

Welcome to the tenth annual Dispatches from the GUILD Conference series. The Gastrointestinal Updates-IBD-Liver Disease (GUILD) Conference is an annual CME conference held in Maui, Hawaii every February (GUILD 2026: […]

Fellows’ Corner

by Archit Garg The patient, a 46-year-old woman, came to the emergency room with three blisters on her right leg, which had appeared a week prior and were getting bigger. […]

A Case Report

Chalk Pica Presenting as Hypercalcemia-Induced Pancreatitis

by Bhaavya Pinnala, Sindhu Naresh, Saleha Asghar Acute pancreatitis is most commonly associated with gallstone disease, chronic alcohol use or hypertriglyceridemia while metabolic abnormalities such as hypercalcemia are far less […]

Frontiers in Endoscopy, Series #103

Ergonomics in Endoscopy

Introduction  Musculoskeletal injuries are prevalent among healthcare workers. Proceduralists, such as gastroenterology (GI) endoscopists, require repetitive and often unnatural movements while maneuvering endoscopes and colonoscopes. The frequent stress and forces […]

NUTRITION REVIEWS IN GASTROENTEROLOGY

Thank You to the 2025 Peer Reviewers of the Nutrition Reviews in Gastroenterology Series

Thank you to the 2025 Peer Reviewers of the Nutrition Reviews in Gastroenterology SeriesWe extend our sincere appreciation to the reviewers of the 2025 Nutrition Reviews inGastroenterology series for their […]

Medical Bulletin Board

American Liver Foundation Celebrates 50 Years of Advancing Liver Health Nationwide

Honoring Five Decades of Progress, Commitment, and Support for Liver Patients (Fairfield, NJ – Jan. 5, 2026) – American Liver Foundation (ALF) proudly announces its 50th anniversary, marking five decades […]

From the Pediatric Literature

Congenital Hepatic Hemangiomas in Children

Most hepatic hemangiomas in infants are benign and are typically divided into two groups: 1) focal hepatic hemangiomas which are congenital and limited in size and 2) infantile hepatic hemangiomas […]

FRONTIERS IN ENDOSCOPY, SERIES #102

Electrohydraulic Lithotripsy for Biliary and Pancreatic Stones

Electrohydraulic lithotripsy (EHL) has emerged as a vital adjunct to endoscopic retrograde cholangiopancreatography (ERCP), providing an effective means of fragmenting large, impacted, or otherwise difficult-to-extract stones within the pancreatic and […]

A Case Report

A Rare Case of Cutaneous Metastasis from Colon Cancer

Colorectal cancer remains the third most common cancer and second most common cause of cancer deaths, often from metastatic disease.1-6 While liver metastases are most common, other sites of metastases […]

Nutrition Reviews in Gastroenterology, SERIES #29

Nutrition Management for Functional Dyspepsia

Functional dyspepsia (FD) is a common disorder of the gut-brain interaction characterized by bothersome symptoms including postprandial fullness, early satiation, epigastric pain, and epigastric burning, without structural disease. Despite its […]

Frontiers in Endoscopy, Series #101

Topical Endoscopic Hemostatic Agents for Gastrointestinal Bleeding

Background Gastrointestinal bleeding (GIB) is associated with significant morbidity and mortality. Despite improved endoscopic practices for GIB, approximately 8-15% of patients fail primary endoscopic therapy, which includes injection, thermal, and […]

Liver Disorders, SERIES #20

Beyond Jaundice Part 2: Recognizing Dermatologic Findings in Chronic Liver Diseases

Chronic liver disease is often accompanied by cutaneous findings indicative of underlying pathology. However, in addition to the many widely-known and recognizable dermatologic manifestations, there exists a multitude of subtle, […]

Frontiers in Endoscopy, Series #100

Pancreaticobiliary Endoscopic Ultrasound: How We Do It

Introduction Endoscopic ultrasound (EUS) has evolved into an indispensable tool in the evaluation and management of pancreaticobiliary diseases. Over 40 years ago, EUS was developed as a radial scanner, providing […]

Nutrition Reviews in Gastroenterology, SERIES #28

The Role of the Mediterranean Diet Pattern in Treatment and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease 

Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by excessive hepatic fat accumulation in individuals without significant alcohol intake. Previously termed non-alcoholic fatty liver disease (NAFLD), this condition included nonalcoholic […]

Special Article

Factors Predicting Patient Follow-Up in Clinic After Anorectal Manometry for Defecatory Disorders in a Community Hospital

Anorectal manometry (ARM) diagnoses anorectal sensorimotor disorders, and biofeedback therapy (BT) is an evidence-based treatment. We conducted a retrospective study at a community hospital to assess factors predicting patient follow-up […]

Liver Disorders, SERIES #19

Beyond Jaundice Part 1: Identifying and Describing Cutaneous Manifestations of Hepatitis and Cirrhosis

Dermatologic findings are common in liver disease, and may represent the very earliest or most prominent signs of an underlying disorder. While most practitioners recognize jaundice as a sign of […]

From the Pediatric Literature

Eosinophilic Esophagitis in Pediatric Patients Receiving Infliximab

The treatment of pediatric inflammatory bowel disease (IBD) has improved markedly with the use of biologic therapy which includes such medications as infliximab. Although infliximab has been used for some […]

Frontiers in Endoscopy, Series #99

Post-Sphincterotomy Bleeding: Incidence, Risk Factors, and Management

Introduction Endoscopic retrograde cholangiopancreaticography (ERCP) is a commonly used therapeutic procedure for diagnostic and therapeutic purposes for various pancreatic-biliary pathologies. Endoscopic sphincterotomy (ES) is a requirement for many biliary interventions. […]

Dispatches from the GUILD Conference, Series #71

Global Consensus Statement for the Management of Inflammatory Bowel Disease in Pregnancy: Implications for the Gastroenterologist

The management of inflammatory bowel disease (IBD) during pregnancy presents unique challenges, requiring a balance between maternal health, disease control, and fetal well-being. A global consensus conference, led by a […]

Liver Disorders, SERIES #18

Understanding New Nomenclature in Advanced Chronic Liver Disease

As understanding of disease processes in medicine evolves, terminology must often evolve too. Terminology related to cirrhosis has been changing to better capture the spectrum of liver disease and patients’ […]

Nutrition Reviews in Gastroenterology, SERIES #27

Gentler Solutions: Adapting the Low FODMAP Elimination Diet for Irritable Bowel Syndrome for Symptom Relief

Irritable Bowel Syndrome (IBS) is a common gastrointestinal (GI) disorder marked by abdominal pain, bloating, and altered bowel habits. Dietary changes are key to managing symptoms, with the low-FODMAP diet […]

Frontiers in Endoscopy, Series #98

Endoscopic Ultrasound-Guided Therapy for Gastric Varices: Current Evidence and Emerging Perspectives

1. Introduction Gastric varices (GV) are a serious complication of portal hypertension, present in about 20% of cirrhotic patients compared to up to 85% with esophageal varices (EV).1,2 Though less […]

Past Issues Archive

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